Annotated Classic The Insulator Activity of CTCF
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چکیده
We are pleased to present a series of Annotated Classics celebrating 40 years of exciting biology in the pages of Cell. This installment revisits “The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators” by Dr. Gary Felsenfeld and his colleagues. Here, Dr. Victor G. Corces comments on the landmark discovery of the insulator activity of CTCF from Felsenfeld, who has pioneered the work decoding the function of CTCF in chromatin organization and transcriptional regulation.
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تاریخ انتشار 2015